APA
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Jarr, K., Ye, J., Kojima, Y., Nanda, V., Flores, A. M., Tsantilas, P., … Leeper, N. (2020). 18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease—Brief Report. Arteriosclerosis, Thrombosis and Vascular Biology.
Chicago/Turabian
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Jarr, K., Jianqin Ye, Y. Kojima, V. Nanda, Alyssa M. Flores, P. Tsantilas, Ying Wang, et al. “18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease—Brief Report.” Arteriosclerosis, Thrombosis and Vascular Biology (2020).
MLA
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Jarr, K., et al. “18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease—Brief Report.” Arteriosclerosis, Thrombosis and Vascular Biology, 2020.
BibTeX Click to copy
@article{k2020a,
title = {18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease—Brief Report},
year = {2020},
journal = {Arteriosclerosis, Thrombosis and Vascular Biology},
author = {Jarr, K. and Ye, Jianqin and Kojima, Y. and Nanda, V. and Flores, Alyssa M. and Tsantilas, P. and Wang, Ying and Hosseini-Nassab, Niloufar and Eberhard, Anne V. and Lotfi, Mozhgan and Käller, Max and Smith, B. and Maegdefessel, L. and Leeper, N.}
}
Supplemental Digital Content is available in the text. Objective: This study sought to determine whether 18F-fluorodeoxyglucose-positron emission tomography/computed tomography could be applied to a murine model of advanced atherosclerotic plaque vulnerability to detect response to therapeutic intervention and changes in lesion stability. Approach and Results: To analyze plaques susceptible to rupture, we fed ApoE−/− mice a high-fat diet and induced vulnerable lesions by cast placement over the carotid artery. After 9 weeks of treatment with orthogonal therapeutic agents (including lipid-lowering and proefferocytic therapies), we assessed vascular inflammation and several features of plaque vulnerability by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography and histopathology, respectively. We observed that 18F-fluorodeoxyglucose-positron emission tomography/computed tomography had the capacity to resolve histopathologically proven changes in plaque stability after treatment. Moreover, mean target-to-background ratios correlated with multiple characteristics of lesion instability, including the corrected vulnerability index. Conclusions: These results suggest that the application of noninvasive 18F-fluorodeoxyglucose-positron emission tomography/computed tomography to a murine model can allow for the identification of vulnerable atherosclerotic plaques and their response to therapeutic intervention. This approach may prove useful as a drug discovery and prioritization method.